The first word that comes to mind is 'inimitable' (ok, we used google translate for that one). Especially his early works are a grand mixture of blues, pop, funk and audio-collages, to name a few.
Apart from visuals, David Lynch was also sound; music often felt like a character in his films and series. Songs lost their innocence through the disturbing scenes in which they shone, and overtly nostalgic music suddenly seemed to come from another world.